Maternal asthma and progeny outcomes
Identifying the gaps in preclinical and clinical knowledge
The prevalence of asthma during pregnancy is on the rise, affecting up to 17% of expectant mothers. Maternal asthma is associated with an increased risk of adverse perinatal outcomes, including conditions like gestational diabetes, pre-eclampsia, preterm birth, and various respiratory issues in neonates. Furthermore, the impact of maternal asthma extends into childhood, increasing the risk of respiratory problems.
Genetic factors alone do not explain these associations; the in utero environment also plays a significant role. Good maternal asthma control during pregnancy reduces risks to both mother and child.
A scoping review is underway, aimed at comprehensively describing preclinical models of maternal asthma and their associated perinatal outcomes. The review will assess the strengths and weaknesses of each model, ensuring methodological rigor in accordance with reporting guidelines. The scoping review will also establish a core outcome set to enhance comparability and translatability of preclinical studies.
While systematic reviews have explored clinical outcomes of maternal asthma in humans, no equivalent synthesis of preclinical data has been undertaken. This scoping review will bridge that gap, shedding light on the alignment between preclinical and clinical findings and identifying gaps and opportunities in current research.
The scoping review protocol is available in the October issue of JBI Evidence Synthesis
Preclinical models of maternal asthma and progeny outcomes: a scoping review protocol
Robinson, Joshua L.; Gatford, Kathy L.; Clifton, Vicki L.; Morrison, Janna L.; Stark, Michael J.
JBI Evidence Synthesis 21(10):p 2115-2126, October 2023. | DOI: 10.11124/JBIES-23-00006