Can immunohistochemical (IHC) biomarkers in oral squamous cell carcinoma (OSCC) be used as prognostic factors for adolescents/young adults?
Patients between 15- to 40-years-old diagnosed with conventional OSCC regardless of country, race and gender who had undergone treatment of the primary lesion.
Studies providing information on IHC biomarkers in OSCC of adolescents/young adults and its prognostic values will be included.
Patients > 40-years-old diagnosed by conventional OSCC regardless of country, race and gender, with provided information on IHC biomarkers and its prognostic values.
The primary outcome includes the correlation of immunohistochemical biomarkers with relapse and death in oral squamous cell carcinoma of adolescents/young adults.
We will use the estimates of prognostic value (hazard ratio and its corresponding 95% confidence Intervals (CIs)) as the effect measures for the main outcome.
Relapse and death due to OSCC
Measures of effect
Calculation of hazard ratio and its corresponding 95% confidence Intervals (CIs) of adolescents/young adults.
Understanding the prognostic value of different biomarkers can be used to predict the agressiveness and progression of OSCC in this population, guiding the treatment approach.