What is the effectiveness of the topical application of phenytoin compared to other forms of topical therapies for healing foot ulcers in adults with diabetes?
People with a clinical diagnosis of diabetes aged 18 years and above and with foot ulceration will be included.
Studies will be eligible for inclusion if they investigate the effect of topical phenytoin in the treatment of foot ulceration in people with diabetes.
This review will consider studies that compare the effect of topical phenytoin to any other intervention (pharmacological or non-pharmacological), different combinations of interventions, or no interventions.
The main outcomes include ulcer healing rate and ulcer size. Relative risks, odds ratios, and/or number needed to treat will be recorded.