1. What is the efficacy of probiotics, prebiotics and synbiotics versus placebo in OS parameters reduction in adults?
2. What is the efficacy of probiotics, prebiotics and synbiotics versus placebo in OS parameters reduction in the specific clinical disorders, such as gestational diabetes, diabetes mellitus type 2, chronic kidney disease, polycystic ovary syndrome, dementia, and psychiatric disorders?
The review will consider studies that include adult (older than 18 years of age) healthy subjects or patients with various diseases.
Probiotics, prebiotics and/or synbiotics
This review will consider studies that assessed parameters of oxidative stress, such as malondialdehyde (MDA), 8-oxo-G, total antioxidant capacity (TAC), total oxidant status (TOS), total oxidant status (TAS), glutathione, glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD), advanced oxidation protein products (AOPP), nitric oxide (NO).