The Grading of Recommendations Assessment, Development and Evaluation (GRADE) reflects ‘best practice’ in terms of clinical guideline development and has been endorsed by organisations across the globe. The JBI Adelaide GRADE Centre is the first GRADE Centre in Australia and New Zealand, and was established in partnership with the GRADE Working Group, an international alliance of clinicians and researchers who have developed a leading approach to rating research quality and guideline development. The Centre's mission is to train, promote, disseminate and implement GRADE approaches within and across the systematic review and guideline development community globally. The JBI Adelaide GRADE Centre offers training in GRADE methods, and expert GRADE consultancy services for guideline development and systematic reviews.